Article
Evaluation of proton-coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts.
American journal of medical genetics. Part A - 1 Apr 2016
VanderMeer Julia E, Carter Tonia C, Pangilinan Faith, Mitchell Adam, Kurnat-Thoma Emma, Kirke Peadar N, Troendle James F, Molloy Anne M, Munger Ronald G, Feldkamp Marcia L, Mansilla Maria A, Mills James L, Murray Jeff C, Brody Lawrence C
Abstract excerpt
Many folate-related genes have been investigated for possible causal roles in neural tube defects (NTDs) and oral clefts. However, no previous reports have examined the major gene responsible for folate uptake, the proton-coupled folate transporter (SLC46A1). We tested for association between these birth defects and single nucleotide polymorphisms in the SLC46A1 gene. The NTD study population included 549...
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