Article
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2008
Mills James L, Molloy Anne M, Parle-McDermott Anne, Troendle James F, Brody Lawrence C, Conley Mary R, Cox Christopher, Pangilinan Faith, Orr David J A, Earley Michael, McKiernan Eamon, Lynn Ena C, Doyle Anne, Scott John M, Kirke Peadar N
Abstract excerpt
BACKGROUND: Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folate-related genes associated with clefts have, however, often been inconclusive. This study examined four SNPs related to folate metabolism (MTHFR 677 C-->T, MTHFR 1298 A-->C, MTHFD1 1958 G-->A, and TC II 776 C-->G) in a large...
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