Article
The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.
Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2009
Molloy Anne M, Brody Lawrence C, Mills James L, Scott John M, Kirke Peadar N
Abstract excerpt
In this paper, we trace the history of current research into the genetic and biochemical mechanisms that underlie folate-preventable neural tube defects (NTDs). The inspired suggestion by Smithells that common vitamins might prevent NTDs ignited a decade of biochemical investigations-first exploring the nutritional and metabolic factors related to NTDs, then onto the hunt for NTD genes. Although NTDs were known...
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