Article
Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.
BMC medical genetics - 8 Oct 2014
Pangilinan Faith, Molloy Anne M, Mills James L, Troendle James F, Parle-McDermott Anne, Kay Denise M, Browne Marilyn L, McGrath Emily C, Abaan Hatice Ozel, Sutton Marie, Kirke Peadar N, Caggana Michele, Shane Barry, Scott John M, Brody Lawrence C
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs), which are among the most common congenital malformations, are influenced by environmental and genetic factors. Low maternal folate is the strongest known contributing factor, making variants in genes in the folate metabolic pathway attractive candidates for NTD risk. Multiple studies have identified nominally significant allelic associations with NTDs. We tested whether...
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