Article
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects.
BMC medical genetics - 2 Aug 2012
Pangilinan Faith, Molloy Anne M, Mills James L, Troendle James F, Parle-McDermott Anne, Signore Caroline, O'Leary Valerie B, Chines Peter, Seay Jessica M, Geiler-Samerotte Kerry, Mitchell Adam, VanderMeer Julia E, Krebs Kristine M, Sanchez Angelica, Cornman-Homonoff Joshua, Stone Nicole, Conley Mary, Kirke Peadar N, Shane Barry, Scott John M, Brody Lawrence C
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are common birth defects (~1 in 1000 pregnancies in the US and Europe) that have complex origins, including environmental and genetic factors. A low level of maternal folate is one well-established risk factor, with maternal periconceptional folic acid supplementation reducing the occurrence of NTD pregnancies by 50-70%. Gene variants in the folate metabolic pathway (e.g.,...
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