Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2016

Afschar Sonita, Toivonen Janne M, Hoffmann Julia Marianne, Tain Luke Stephen, Wieser Daniela, Finlayson Andrew John, Driege Yasmine, Alic Nazif, Emran Sahar, Stinn Julia, Froehlich Jenny, Piper Matthew D, Partridge Linda

Abstract excerpt

Lifespan of laboratory animals can be increased by genetic, pharmacological, and dietary interventions. Increased expression of genes involved in xenobiotic metabolism, together with resistance to xenobiotics, are frequent correlates of lifespan extension in the nematode worm Caenorhabditis elegans, the fruit fly Drosophila, and mice. The Green Theory of Aging suggests that this association is causal, with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Insulin

Share to Life Expectancy

Share to Receptors, Cytoplasmic and Nuclear

Share to Transcription, Genetic

Share to Xenobiotics

Source

Open in PubMed Open full text

Identifiers

PMID: 26787908
DOI: 10.1073/pnas.1515137113
PMCID: PMC4747718

Genes

DDT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila.PMID 26787908Read ↗

dFOXO-independent effects of reduced insulin-like signaling in Drosophila.Semantic proximity Read ↗

Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants.Semantic proximity Read ↗

Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan.Semantic proximity Read ↗

Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan.Semantic proximity Read ↗

Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal.Semantic proximity Read ↗

End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologiesSemantic proximity Read ↗

A heteroallelic Drosophila insulin-like receptor mutant and its use in validating physiological activities of food constituents.Semantic proximity Read ↗

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.Semantic proximity Read ↗

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.Semantic proximity Read ↗

Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice.Semantic proximity Read ↗

Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster.Semantic proximity Read ↗

ADrosophilamodel for fetal alcohol syndrome disorders: role for the insulin pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.