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Article

Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan.

Cell metabolism - 7 Jan 2014

Mahanti Parag, Bose Neelanjan, Bethke Axel, Judkins Joshua C, Wollam Joshua, Dumas Kathleen J, Zimmerman Anna M, Campbell Sydney L, Hu Patrick J, Antebi Adam, Schroeder Frank C

Abstract excerpt

Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional regulation of metazoan development, cell differentiation, and metabolism. However, the physiological ligands of many NHRs remain poorly characterized, primarily due to lack of robust analytical techniques. Using comparative metabolomics, we identified endogenous steroids that act as ligands of the C. elegans NHR, DAF-12, a...

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Source

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Identifiers

PMID: 24411940
DOI: 10.1016/j.cmet.2013.11.024
PMCID: PMC3924769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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