Article
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
Science (New York, N.Y.) - 6 Apr 2001
Tatar M, Kopelman A, Epstein D, Tu M P, Yin C M, Garofalo R S
Abstract excerpt
The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2, a signal transducer regulating worm dauer formation and adult longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific...
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