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Article

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.

Critical reviews in oncology/hematology - 1 Sept 2013

Anisimov Vladimir N, Bartke Andrzej

Abstract excerpt

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. GH/Insulin/insulin-like growth factor-1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases lifespan in nematodes, fruit flies and mice. The life-prolonging effects of caloric...

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Identifiers

PMID: 23434537
DOI: 10.1016/j.critrevonc.2013.01.005
PMCID: PMC4095988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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