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Article

dFOXO-independent effects of reduced insulin-like signaling in Drosophila.

Aging cell - 1 Oct 2011

Slack Cathy, Giannakou Maria E, Foley Andrea, Goss Martin, Partridge Linda

Abstract excerpt

The insulin/insulin-like growth factor-like signaling (IIS) pathway in metazoans has evolutionarily conserved roles in growth control, metabolic homeostasis, stress responses, reproduction, and lifespan. Genetic manipulations that reduce IIS in the nematode worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the mouse have been shown not only to produce substantial increases in lifespan but...

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Identifiers

PMID: 21443682
DOI: 10.1111/j.1474-9726.2011.00707.x
PMCID: PMC3193374

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