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Article

Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan.

Aging - 13 Dec 2020

Brinkmann Vanessa, Schiavi Alfonso, Shaik Anjumara, Puchta Daniel Rüdiger, Ventura Natascia

Abstract excerpt

Genetic, dietary, and environmental factors concurrently shape the aging process. The aryl hydrocarbon receptor (AhR) was discovered as a dioxin-binding transcription factor involved in the metabolism of different environmental toxicants in vertebrates. Since then, the variety of pathophysiological processes regulated by the AhR has grown, ranging from immune response, metabolic pathways, and aging. Many...

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PMID: 33349622
DOI: 10.18632/aging.202316
PMCID: PMC7835051

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