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Article

Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice.

The Journal of biological chemistry - 22 Apr 2005

Baba Tomonori, Shimizu Takahiko, Suzuki Yo-Ichi, Ogawara Midori, Isono Kyo-Ichi, Koseki Haruhiko, Kurosawa Hisashi, Shirasawa Takuji

Abstract excerpt

To investigate the biological significance of a longevity mutation found in daf-2 of Caenorhabditis elegans, we generated a homologous murine model by replacing Pro-1195 of insulin receptors with Leu using a targeted knock-in strategy. Homozygous mice died in the neonatal stage from diabetic ketoacidosis, whereas heterozygous mice showed the suppressed kinase activity of the insulin receptor but grew normally...

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PMID: 15713666
DOI: 10.1074/jbc.M500924200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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