Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: A critical review

13 Jun 2015

Abstract excerpt

Early life stress (ELS) is a known risk factor for suffering psychopathology in adulthood. The hypothalamic-pituitary-adrenal (HPA) axis has been described to be deregulated in both individuals who experienced early psychosocial stress and in patients with a wide range of psychiatric disorders. The NR3C1 gene codes for the glucocorticoid receptor, a key element involved in several steps of HPA axis modulation. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Early Childhood Education and Development
Share to Stress Responses and Cortisol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26073068
DOI: 10.1016/j.neubiorev.2015.05.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: A critical reviewPMID 26073068Read ↗

Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review.Semantic proximity Read ↗

Glucocorticoid receptor gene (NR3C1) promoter is hypermethylated in Thai females with major depressive disorder.Semantic proximity Read ↗

Glucocorticoid receptor gene (NR3C1) methylation following stressful events between birth and adolescence. The TRAILS studySemantic proximity Read ↗

Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disordersSemantic proximity Read ↗

Increased methylation at an unexplored glucocorticoid responsive element within exon 1D of NR3C1 gene is related to anxious-depressive disorders and decreased hippocampal connectivity.Semantic proximity Read ↗

Associations Between Early Life Stress and Gene Methylation in ChildrenSemantic proximity Read ↗

Epigenetic modification of the glucocorticoid receptor gene is linked to traumatic memory and post-traumatic stress disorder risk in genocide survivors.Semantic proximity Read ↗

Epigenetic Modifications in Stress Response Genes Associated With Childhood TraumaSemantic proximity Read ↗

Human DNA methylation and the cortisol response to an acute psychological stressor: a systematic review and meta-analysisSemantic proximity Read ↗

Epigenetic modifications of the glucocorticoid receptor gene are associated with the vulnerability to psychopathology in childhood maltreatment.Semantic proximity Read ↗

Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disordersSemantic proximity Read ↗

Prenatal earthquake stress exposure in different gestational trimesters is associated with methylation changes in the glucocorticoid receptor gene (NR3C1) and long-term working memory in adulthoodSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.