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Article

Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review.

Neuroscience and biobehavioral reviews - 1 Dec 2018

Watkeys Oliver J, Kremerskothen Kyle, Quidé Yann, Fullerton Janice M, Green Melissa J

Abstract excerpt

The glucocorticoid receptor gene (NR3C1) is a critical component of the stress response system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and mental disorders, including major depression, post-traumatic stress disorder, anxiety, and personality disorders, suggesting that NR3C1 methylation may play a role in stress-related psychopathology. We systematically reviewed 55 studies...

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Variation

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Share to Receptors, Glucocorticoid

Share to Stress, Psychological

Source

Identifiers

PMID: 30176278
DOI: 10.1016/j.neubiorev.2018.08.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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