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Article

Association between NR3C1 rs41423247 polymorphism and depression

1 Sept 2018

Abstract excerpt

BACKGROUND: A dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is closely related to the occurrence of depression. The glucocorticoid receptor, also known as the nuclear receptor subfamily 3, group C, member 1 (NR3C1), provides negative feedback to the HPA axis by binding to glucocorticoids. Some studies have demonstrated an association between the NR3C1 rs41423247 polymorphism and depression, but...

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PMID: 30278546
DOI: 10.1097/md.0000000000012541

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