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Article

Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs.

BMC genomics - 19 Jan 2016

Wappett Mark, Dulak Austin, Yang Zheng Rong, Al-Watban Abdullatif, Bradford James R, Dry Jonathan R

Abstract excerpt

BACKGROUND: Identification of synthetic lethal interactions in cancer cells could offer promising new therapeutic targets. Large-scale functional genomic screening presents an opportunity to test large numbers of cancer synthetic lethal hypotheses. Methods enriching for candidate synthetic lethal targets in molecularly defined cancer cell lines can steer effective design of screening efforts. Loss of one partner...

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Identifiers

PMID: 26781748
DOI: 10.1186/s12864-016-2375-1
PMCID: PMC4717622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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