Article
Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 2014
Petousi Nayia, Croft Quentin P P, Cavalleri Gianpiero L, Cheng Hung-Yuan, Formenti Federico, Ishida Koji, Lunn Daniel, McCormack Mark, Shianna Kevin V, Talbot Nick P, Ratcliffe Peter J, Robbins Peter A
Abstract excerpt
Tibetan natives have lived on the Tibetan plateau (altitude ∼ 4,000 m) for at least 25,000 years, and as such they are adapted to life and reproduction in a hypoxic environment. Recent studies have identified two genetic loci, EGLN1 and EPAS1, that have undergone natural selection in Tibetans, and further demonstrated an association of EGLN1/EPAS1 genotype with hemoglobin concentration. Both genes encode major...
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