Article
Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia.
Molecular biology and evolution - 1 Apr 2017
Peng Yi, Cui Chaoying, He Yaoxi, Ouzhuluobu, Zhang Hui, Yang Deying, Zhang Qu, Bianbazhuoma, Yang Lixin, He Yibo, Xiang Kun, Zhang Xiaoming, Bhandari Sushil, Shi Peng, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan Yongyue, Cirenyangji, Baimayangji, Gonggalanzi, Bai Caijuan, Bianba, Basang, Ciwangsangbu, Xu Shuhua, Chen Hua, Liu Shiming, Wu Tianyi, Qi Xuebin, Su Bing
Abstract excerpt
Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses of EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with the strongest signal of selection in previous genome-wide scans of Tibetans. We showed that the Tibetan-enriched EPAS1 variants down-regulate expression...
Topics
- Acclimatization
- Adaptation, Biological
- Adaptation, Physiological
- Adult
- Altitude
- Altitude Sickness
- Animals
- Basic Helix-Loop-Helix Transcription Factors