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Article

Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China.

Microbiology spectrum - 7 Jul 2026

Bo Xiang-Long, Li Ma-Chao, Hang Hao, Lin Shi-Qiang, Liu Hai-Can, Qian Cheng, Li Gui-Lian, Zhao Xiu-Qin, Wan Kang-Lin, Zhao Li-Li

Abstract excerpt

To investigate the effects of mutations on pyrazinamide (PZA)-associated regions, including pncA, rpsA, panD, and clpC1, among multidrug-resistant tuberculosis (MDR-TB) isolates from China. A total of 139 MDR-TB isolates from China underwent PZA susceptibility testing and genotyping, and the sequences of the four PZA resistance-associated regions were analyzed. The association between lineage and PZA resistance...

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Identifiers

PMID: 42159504
DOI: 10.1128/spectrum.00641-26
PMCID: PMC13340127

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