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The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China.

Emerging microbes & infections - 1 Dec 2025

Wang Nan, Meng Fanrong, Deng Li, Wu Ling, Yang Yu, Li Hua, Chen Yuanjin, Wei Zeyou, Xie Bei, Gong Lan, Niu Qun, Lei Jie, Gao Junwen, Huang Bo, Wang Qi, Lai Xiaomin, Liu Zhihui, Hu Jinxing

Abstract excerpt

This study investigates the epidemic trend of pyrazinamide (PZA)-resistant tuberculosis in Southern China over 11 years (2012-2022) and evaluates the mutation characteristics of PZA resistance-related genes (pncA, rpsA, and panD) in clinical Mycobacterium tuberculosis (M. tuberculosis) isolates. To fulfil these goals, we analyzed the phenotypic PZA resistance characteristics of 14,927 clinical isolates for which...

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Amidohydrolases
Antitubercular Agents
China
Drug Resistance, Bacterial
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium tuberculosis

Tuberculosis, Multidrug-Resistant

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PMID: 39745172
DOI: 10.1080/22221751.2024.2447607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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