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Article

Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease.

Cell - 14 Jan 2016

Yang Chiao-Wen, Hojer Caroline D, Zhou Meijuan, Wu Xiumin, Wuster Arthur, Lee Wyne P, Yaspan Brian L, Chan Andrew C

Abstract excerpt

The DENN domain is an evolutionary conserved protein module found in all eukaryotes and serves as an exchange factor for Rab-GTPases to regulate diverse cellular functions. Variants in DENND1B are associated with development of childhood asthma and other immune disorders. To understand how DENND1B may contribute to human disease, Dennd1b(-/-) mice were generated and exhibit hyper-allergic responses following...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26774822
DOI: 10.1016/j.cell.2015.11.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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