Article
Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.
The Journal of experimental medicine - 1 May 2017
Moffitt Andrea B, Ondrejka Sarah L, McKinney Matthew, Rempel Rachel E, Goodlad John R, Teh Chun Huat, Leppa Sirpa, Mannisto Susanna, Kovanen Panu E, Tse Eric, Au-Yeung Rex K H, Kwong Yok-Lam, Srivastava Gopesh, Iqbal Javeed, Yu Jiayu, Naresh Kikkeri, Villa Diego, Gascoyne Randy D, Said Jonathan, Czader Magdalena B, Chadburn Amy, Richards Kristy L, Rajagopalan Deepthi, Davis Nicholas S, Smith Eileen C, Palus Brooke C, Tzeng Tiffany J, Healy Jane A, Lugar Patricia L, Datta Jyotishka, Love Cassandra, Levy Shawn, Dunson David B, Zhuang Yuan, Hsi Eric D, Dave Sandeep S
Abstract excerpt
Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3,...
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