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Article

Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children.

Molecular immunology - 1 Oct 2017

Fiuza Bianca S D, Silva Milca de J, Alcântara-Neves Neuza M, Barreto Maurício L, Costa Ryan Dos S, Figueiredo Camila A

Abstract excerpt

Asthma is a heterogeneous disease associated with a complex basis involving environmental factors and individual variabilities. The DENN Domain Containing 1B (DENND1B) gene has an important role on T cell receptor (TCR) down-regulation on Th2 cells and studies have shown that mutations or loss of this factor can be associated with increased Th2 responses and asthma. The aim of this work is to evaluate the...

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PMID: 28668455
DOI: 10.1016/j.molimm.2017.06.030

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