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Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1

7 Apr 2017

Abstract excerpt

BACKGROUND: The transcription factor Ets1 is highly expressed in B lymphocytes. Loss of Ets1 leads to premature B cell differentiation into antibody-secreting cells (ASCs), secretion of autoantibodies, and development of autoimmune disease. Despite the importance of Ets1 in B cell biology, few Ets1 target genes are known in these cells. RESULTS: To obtain a more complete picture of the function of Ets1 in...

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PMID: 28439269
DOI: 10.3389/fimmu.2017.00383

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