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Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases.

eNeuro - 1 Jan 2019

Cuevas-Diaz Duran Raquel, Wang Chih-Yen, Zheng Hui, Deneen Benjamin, Wu Jia Qian

Abstract excerpt

Currently, there are no effective treatments for glioma or for neurodegenerative diseases because of, in part, our limited understanding of the pathophysiology and cellular heterogeneity of these diseases. Mounting evidence suggests that astrocytes play an active role in the pathogenesis of these diseases by contributing to a diverse range of pathophysiological states. In a previous study, five molecularly...

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PMID: 30957015
DOI: 10.1523/ENEURO.0288-18.2019
PMCID: PMC6449165

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