Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.

The American journal of pathology - 1 Sept 2005

Shannon Patrick, Sabha Nesrin, Lau Nelson, Kamnasaran Deepak, Gutmann David H, Guha Abhijit

Abstract excerpt

We previously characterized a genetically engineered mouse astrocytoma model with embryonic astrocyte-specific, activated (12)V-Ha-RAS (GFAP-RAS) transgenesis. The GFAP-RAS line Ras-B8 appears normal at birth, but 50% of mice die by 4 months from low- and high-grade astrocytomas. We examined the development and progression of astrocytomas in the Ras-B8 genetically engineered mouse. At embryonic day 16.5 (E16.5),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Astrocytoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System Neoplasms

Share to Genes, ras

Share to Glial Fibrillary Acidic Protein

Share to Growth Substances

Share to Hyperplasia

Share to Mice, Inbred ICR

Source

Open in PubMed Open full text

Identifiers

PMID: 16127163
DOI: 10.1016/S0002-9440(10)62057-3
PMCID: PMC1698742

Genes

GFAP
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.PMID 16127163Read ↗

Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.Semantic proximity Read ↗

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.Semantic proximity Read ↗

Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma.Semantic proximity Read ↗

<i>GATA6</i> is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma modelSemantic proximity Read ↗

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models.Semantic proximity Read ↗

GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a <i>Trp53 null</i> backgroundSemantic proximity Read ↗

Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.Semantic proximity Read ↗

Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasisSemantic proximity Read ↗

Importance of GFAP isoform‐specific analyses in astrocytomaSemantic proximity Read ↗

The Characteristics of Astrocytomas and Oligodendrogliomas Are Caused by Two Distinct and Interchangeable Signaling FormatsSemantic proximity Read ↗

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects.Semantic proximity Read ↗

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.