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Article

Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro.

Translational psychiatry - 12 Jan 2016

Tropea D, Molinos I, Petit E, Bellini S, Nagakura I, O'Tuathaigh C, Schorova L, Mitchell K J, Waddington J, Sur M, Gill M, Corvin A P

Abstract excerpt

Major neuropsychiatric disorders are genetically complex but share overlapping etiology. Mice mutant for rare, highly penetrant risk variants can be useful in dissecting the molecular mechanisms involved. The gene disrupted in schizophrenia 1 (DISC1) has been associated with increased risk for neuropsychiatric conditions. Mice mutant for Disc1 display morphological, functional and behavioral deficits that are...

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Identifiers

PMID: 26756905
DOI: 10.1038/tp.2015.206
PMCID: PMC5068880

Genes

DISC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro.PMID 26756905Read ↗

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