Article
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
Proceedings of the National Academy of Sciences of the United States of America - 4 Sept 2007
Hikida Takatoshi, Jaaro-Peled Hanna, Seshadri Saurav, Oishi Kenichi, Hookway Caroline, Kong Stephanie, Wu Di, Xue Rong, Andradé Manuella, Tankou Stephanie, Mori Susumu, Gallagher Michela, Ishizuka Koko, Pletnikov Mikhail, Kida Satoshi, Sawa Akira
Abstract excerpt
Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a promising genetic risk factor for major mental illnesses. In this transgenic model, a dominant-negative form of DISC1 (DN-DISC1) is expressed under the alphaCaMKII promoter. In vivo MRI of the DN-DISC1 mice detected...
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