Article

Knock-down of hippocampal DISC1 in immune-challenged mice impairs the prefrontal-hippocampal coupling and the cognitive performance throughout development

2020-05-03

Abstract excerpt

Disrupted-in-Schizophrenia 1 (DISC1) gene represents an intracellular hub of developmental processes and has been related to cognitive dysfunction in psychiatric disorders. Mice with whole-brain DISC1 knock-down show memory and executive deficits as result of impaired prefrontal-hippocampal communication throughout development, especially when combined with early environmental stressors, such as maternal immune ac...

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Literature Corpus work: 7ee78846-568c-5391-a786-d6191d715ac3
DOI: 10.1101/2020.05.01.070300

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