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Article

NEURODEVELOPMENT. Adult cortical plasticity depends on an early postnatal critical period.

Science (New York, N.Y.) - 24 Jul 2015

Greenhill Stuart D, Juczewski Konrad, de Haan Annelies M, Seaton Gillian, Fox Kevin, Hardingham Neil R

Abstract excerpt

Development of the cerebral cortex is influenced by sensory experience during distinct phases of postnatal development known as critical periods. Disruption of experience during a critical period produces neurons that lack specificity for particular stimulus features, such as location in the somatosensory system. Synaptic plasticity is the agent by which sensory experience affects cortical development. Here, we...

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Source

Identifiers

PMID: 26206934
DOI: 10.1126/science.aaa8481

Genes

DISC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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