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Article

Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits.

Molecular brain - 12 Oct 2016

Cui Lin, Sun Wei, Yu Ming, Li Nan, Guo Li, Gu Huating, Zhou Yu

Abstract excerpt

Disrupted-in-schizophrenia 1(DISC1) is a promising candidate susceptibility gene for a spectrum of psychiatric illnesses that share cognitive impairments in common, including schizophrenia, bipolar disorder and major depression. Here we report that DISC1 L100P homozygous mutant shows normal anxiety- and depression-like behavior, but impaired object recognition which is prevented by administration of atypical...

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Identifiers

PMID: 27729083
DOI: 10.1186/s13041-016-0270-y
PMCID: PMC5059944

Genes

DISC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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