Article
No selection of CXCR4-using variants in cell reservoirs of dual-mixed HIV-infected patients on suppressive maraviroc therapy.
AIDS (London, England) - 27 Mar 2016
Raymond Stéphanie, Nicot Florence, Carcenac Romain, Jeanne Nicolas, Cazabat Michelle, Requena Mary, Cuzin Lise, Delobel Pierre, Izopet Jacques
Abstract excerpt
We used ultradeep sequencing to investigate the evolution of the frequency of CXCR4-using viruses in the peripheral blood mononuclear cells of 22 patients infected with both CCR5 and CXCR4-using viruses treated with the CCR5 antagonist maraviroc for 24 weeks and a stable antiviral therapy. The mean CXCR4-using virus frequency in peripheral blood mononuclear cells was 59% before maraviroc intensification and 52%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.