Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotypic and phenotypic characteristics of CXCR4-using transmitted/founder HIV-1 envelope glycoproteins.

Journal of virology - 23 Jun 2026

Martres Dorine, Montagné Théo, Pani Sandra, Jeanne Nicolas, Armani-Tourret Marie, Requena Mary, Vellas Camille, Raymond Stéphanie, Lorin Valérie, Gallois Yohan, Puissant-Lubrano Bénédicte, Mouquet Hugo, Delobel Pierre, Izopet Jacques, Lagane Bernard

Abstract excerpt

The characteristics of HIV-1 envelope glycoproteins (Env) that initiate infection remain incompletely understood. In the primary HIV infection (PHI) stage, Envs using CCR5 as entry coreceptor (R5-tropic Envs) are much more frequent than those using CXCR4, alone or in addition to CCR5 (X4 or R5X4 Envs). However, a comprehensive analysis of the genetic identity and functional properties of CXCR4-using Envs during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Antibodies

Share to HIV Envelope Protein gp120

Share to HIV Envelope Protein gp41

Share to HIV Infections

Share to Receptors, CCR5

Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 42132422
DOI: 10.1128/jvi.00067-26
PMCID: PMC13288616

Genes

CXCR4
CCR5
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotypic and phenotypic characteristics of CXCR4-using transmitted/founder HIV-1 envelope glycoproteins.PMID 42132422Read ↗

Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing StrainsSemantic proximity Read ↗

CXCR4-using viruses in plasma and peripheral blood mononuclear cells during primary HIV-1 infection and impact on disease progression.Semantic proximity Read ↗

Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C.Semantic proximity Read ↗

Phenotypic properties of transmitted founder HIV-1.Semantic proximity Read ↗

Evolution driven by a varying host environment selects for distinct HIV-1 entry phenotypes and other informative variantsSemantic proximity Read ↗

Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.Semantic proximity Read ↗

Correlation of coreceptor usage and disease progressionSemantic proximity Read ↗

Rapid CD4 cell loss is caused by specific CRF01_AE cluster with V3 signatures favoring CXCR4 usageSemantic proximity Read ↗

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection.Semantic proximity Read ↗

Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C InfectionSemantic proximity Read ↗

Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences.Semantic proximity Read ↗

Comprehensive Characterization of the Transmitted/Founder env Genes From a Single MSM Cohort in China.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.