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Article

Next generation sequencing reveals a high frequency of CXCR4 utilizing viruses in HIV-1 chronically infected drug experienced individuals in South Africa.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2018

Matume Nontokozo D, Tebit Denis M, Gray Laurie R, Hammarskjold Marie-Louise, Rekosh David, Bessong Pascal O

Abstract excerpt

BACKGROUND: Entry inhibitors, such as Maraviroc, bind to CCR5 inhibiting entry of CCR5 utilizing viruses (R5 viruses). In the course of HIV infection, CXCR4 utilizing viruses (X4 viruses) may emerge and outgrow R5 viruses, and potentially limit the effectiveness of Maraviroc. The use of Maraviroc is reserved for salvage therapy in South Africa. OBJECTIVE: In this study, we examined the frequency of R5 and X4...

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Share to Anti-Retroviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CXCR4

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Source

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Identifiers

PMID: 29661652
DOI: 10.1016/j.jcv.2018.02.008
PMCID: PMC7229640

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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