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Article

Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing.

AIDS (London, England) - 19 Jun 2009

Archer John, Braverman Michael S, Taillon Bruce E, Desany Brian, James Ian, Harrigan P Richard, Lewis Marilyn, Robertson David L

Abstract excerpt

OBJECTIVE: Identification of low-frequency variants is of clinical importance in the identification of preexisting drug resistance. Using 'ultra-deep' sequencing, we address the detection of potential resistance to the chemokine (C-C motif) receptor 5 (CCR5) antagonist, maraviroc, due to the pretreatment presence of low levels of chemokine (CXC motif) receptor 4 (CXCR4)-using virus. METHODS: We present a novel...

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Source

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Identifiers

PMID: 19424056
DOI: 10.1097/QAD.0b013e32832b4399
PMCID: PMC2857961

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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