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Article

Deep sequencing to infer HIV-1 co-receptor usage: application to three clinical trials of maraviroc in treatment-experienced patients.

The Journal of infectious diseases - 15 Jan 2011

Swenson Luke C, Mo Theresa, Dong Winnie W Y, Zhong Xiaoyin, Woods Conan K, Jensen Mark A, Thielen Alexander, Chapman Douglass, Lewis Marilyn, James Ian, Heera Jayvant, Valdez Hernan, Harrigan P Richard

Abstract excerpt

BACKGROUND: The Maraviroc versus Optimized Therapy in Viremic Antiretroviral Treatment-Experienced Patients (MOTIVATE) studies compared maraviroc versus placebo in treatment-experienced patients with CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1), screened using the original Trofile assay. A subset with non-R5 HIV infection entered the A4001029 trial. We retrospectively examined the performance of a...

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Identifiers

PMID: 21288824
DOI: 10.1093/infdis/jiq030
PMCID: PMC3071057

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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