Article
Local True Discovery Rate Weighted Polygenic Scores Using GWAS Summary Data.
Behavior genetics - 1 Jul 2016
Mak Timothy Shin Heng, Kwan Johnny Sheung Him, Campbell Desmond Dedalus, Sham Pak Chung
Abstract excerpt
A polygenic score is commonly derived using genome-wide genotype data to summarize the genetic contribution to a particular disease at the individual level. Usually it is constructed as a linear combination of SNP genotype weighted by the SNP-wise regression coefficient of the SNP to the phenotype using SNPs with p values smaller than a particular threshold. Commonly a range of thresholds are used which can pose...
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