Article
Genetically correlated effects of selective breeding for high and low methamphetamine consumption.
Genes, brain, and behavior - 1 Nov 2009
Wheeler J M, Reed C, Burkhart-Kasch S, Li N, Cunningham C L, Janowsky A, Franken F H, Wiren K M, Hashimoto J G, Scibelli A C, Phillips T J
Abstract excerpt
Improved prevention and treatment of drug addiction will require deeper understanding of genetic factors contributing to susceptibility to excessive drug use. Intravenous operant self-administration methods have greatly advanced understanding of behavioral traits related to addiction. However, these methods are not suitable for large-scale genetic experiments in mice. Selective breeding of mice can aggregate...
Topics
- Administration, Oral
- Amphetamine-Related Disorders
- Animals
- Apoptosis
- Avoidance Learning
- Breeding
- Central Nervous System Stimulants
- Conditioning, Psychological
- Disease Models, Animal
- Dose-Response Relationship, Drug