Back to search

Article

Assessment of behavioral flexibility in mice with conditional deletion of metabotropic glutamate receptor 2 from <i>Emx1</i> -lineage neurons

2023-09-18

Abstract excerpt

Convergent lines of evidence from animal models suggest that disrupted metabotropic glutamate receptor 2 (mGlu 2 ) function promotes high levels of drug consumption for a variety of psychoactive drugs including alcohol, opioids, and psychostimulants. In both rodents and humans, impaired behavioral flexibility prior to first drug use correlates with high levels of drug consumption later in life. Thus, we posited t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
43b4a324-065e-518c-a860-c2dac8f1de63
DOI
10.1101/2023.09.15.558004
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Assessment of behavioral flexibility in mice with conditional deletion of metabotropic glutamate receptor 2 from <i>Emx1</i> -lineage neuronsDOI 10.1101/2023.09.15.558004
Prefrontal glutamate correlates of methamphetamine sensitization and preference.Semantic proximity
Behavioral, neurotransmitter and transcriptomic analyses in male and female Fmr1 KO miceSemantic proximity
Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome.Semantic proximity
Immp2l knockdown increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a mouse model of Tourette syndrome and autism spectrum disorderSemantic proximity
Modelling Differential Vulnerability to Substance Use Disorder in Rodents: Neurobiological Mechanisms.Semantic proximity
Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking?Semantic proximity
Parallel learning and cognitive flexibility impairments between Fmr1 knockout mice and individuals with fragile X syndromeSemantic proximity
Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats.Semantic proximity
Sex-dependent Schizophrenia and Drug Reward Behavioral Phenotypes in Metabotropic Glutamate 5 Receptor Heterozygous and Homozygous Mice.Semantic proximity
<i>Tmod2</i> is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticitySemantic proximity
Behavioral and genetic markers of susceptibility to escalate fentanyl intakeSemantic proximity
Gene expression differences in mice divergently selected for methamphetamine sensitivity.Semantic proximity
Select a neighboring publication to make it the new centre.