G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old.

doi:10.1007/s11357-015-9869-7

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G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old.

Age (Dordrecht, Netherlands) - 1 Feb 2016

Hao Qiukui, Ding Xiang, Gao Langli, Yang Ming, Dong Birong

Abstract excerpt

This study aimed to examine the possible association between G-395A polymorphism in the promoter region of the KLOTHO gene and cognitive impairment among Chinese nonagenarians and centenarians. This study is a secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study. Community-dwelling Chinese people aged 90 years or older were included. G-395A (rs1207568) genotyping in the promoter...

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Identifiers

PMID: 26732817
DOI: 10.1007/s11357-015-9869-7
PMCID: PMC5005865

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