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Article

G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old.

Scientific reports - 30 Apr 2018

Hao Qiukui, Wang Yuting, Ding Xiang, Dong Biao, Yang Ming, Dong Birong, Wei Yuquan

Abstract excerpt

Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and...

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Identifiers

PMID: 29712948
DOI: 10.1038/s41598-018-25040-4
PMCID: PMC5928057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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