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Article

KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The São Paulo Ageing & Health (SPAH) Study.

Scientific reports - 22 May 2020

Pereira Rosa Maria R, Freitas Thiago Quadrante, Franco André Silva, Takayama Liliam, Caparbo Valeria F, Domiciano Diogo S, Machado Luana G, Figueiredo Camille P, Menezes Paulo R, Onuchic Luiz Fernando, de Castro Isac

Abstract excerpt

Defective KLOTHO gene expression in mice led to a syndrome resembling human ageing. This study evaluated three KLOTHO polymorphisms, namely G395A, C1818T, and C370S, in an elderly population (mean age of 73 years) and their associations with ageing-related outcomes (cardiovascular events, kidney function, osteoporosis, sarcopenia) and mortality. Estimated glomerular filtration rates (eGFR) was lower in subjects...

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Identifiers

PMID: 32444684
DOI: 10.1038/s41598-020-65441-y
PMCID: PMC7244540

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