G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals.

doi:10.4238/2015.November.30.22

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G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals.

Genetics and molecular research : GMR - 1 Dec 2015

Gao L L, Ding X, Xie D M, Yang M, Dong B R

Abstract excerpt

The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The expression of the A allele of the KLOTHO...

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PMID: 26634510
DOI: 10.4238/2015.November.30.22

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