Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA double-strand break repair: a tale of pathway choices

24 May 2016

Abstract excerpt

Deoxyribonucleic acid double-strand breaks (DSBs) are cytotoxic lesions that must be repaired either through homologous recombination (HR) or non-homologous end-joining (NHEJ) pathways. DSB repair is critical for genome integrity, cellular homeostasis and also constitutes the biological foundation for radiotherapy and the majority of chemotherapy. The choice between HR and NHEJ is a complex yet not completely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27217474
DOI: 10.1093/abbs/gmw045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA double-strand break repair: a tale of pathway choicesPMID 27217474Read ↗

Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancerSemantic proximity Read ↗

DNA double-strand break repair pathway choice - from basic biology to clinical exploitationSemantic proximity Read ↗

Early events in the mammalian response to DNA double-strand breaksSemantic proximity Read ↗

The DNA double-strand break response pathway: becoming more BRCAish than ever.Semantic proximity Read ↗

Pathway choice in DNA double strand break repair: observations of a balancing actSemantic proximity Read ↗

Repair Pathway Choices and Consequences at the Double-Strand Break.Semantic proximity Read ↗

DNA repair pathways in breast cancer: from mechanisms to clinical applications.Semantic proximity Read ↗

DNA double-strand break repair in a cellular context.Semantic proximity Read ↗

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapySemantic proximity Read ↗

The role of BRCA1 in DNA double-strand repair: past and present.Semantic proximity Read ↗

Overview of Roles of Novel Components in the Regulation of DNA Damage Repair in BRCA1-deficient Cancers: An UpdateSemantic proximity Read ↗

Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway ChoiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.