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Article

FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku.

Nature communications - 24 Apr 2020

Jin Hanyong, Lee Boeun, Luo Yongyang, Choi Yuri, Choi Eui-Hwan, Jin Hong, Kim Kee-Beom, Seo Sang Beom, Kim Yong-Hak, Lee Hyung Ho, Kim Keun Pil, Lee Kangseok, Bae Jeehyeon

Abstract excerpt

The balance between major DNA double-strand break (DSB) repair pathways is influenced by binding of the Ku complex, a XRCC5/6 heterodimer, to DSB ends, initiating non-homologous end joining (NHEJ) but preventing additional DSB end resection and homologous recombination (HR). However, the key molecular cue for Ku recruitment to DSB sites is unknown. Here, we report that FOXL2, a forkhead family transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Box Protein L2

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Source

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Identifiers

PMID: 32332759
DOI: 10.1038/s41467-020-15748-1
PMCID: PMC7181608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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