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Article

Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway Choice

9 Dec 2013

Abstract excerpt

The p53-binding protein 1 (53BP1) is a well-known DNA damage response (DDR) factor, which is recruited to nuclear structures at the site of DNA damage and forms readily visualized ionizing radiation (IR) induced foci. Depletion of 53BP1 results in cell cycle arrest in G2/M phase as well as genomic instability in human as well as mouse cells. Within the DNA damage response mechanism, 53BP1 is classified as an...

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PMID: 24320053
DOI: 10.1667/rr13572.1

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