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Article

The role of BRCA1 in DNA damage response.

Protein & cell - 1 Feb 2010

Wu Jiaxue, Lu Lin-Yu, Yu Xiaochun

Abstract excerpt

BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this...

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Source

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Identifiers

PMID: 21203981
DOI: 10.1007/s13238-010-0010-5
PMCID: PMC3078634

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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