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Article

GABBR1 and SLC6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations.

Alcoholism, clinical and experimental research - 1 Jan 2016

Enoch Mary-Anne, Hodgkinson Colin A, Shen Pei-Hong, Gorodetsky Elena, Marietta Cheryl A, Roy Alec, Goldman David

Abstract excerpt

BACKGROUND: Animal and human studies indicate that GABBR1, encoding the GABAB1 receptor subunit, and SLC6A1, encoding the neuronal gamma-aminobutyric acid (GABA) transporter GAT1, play a role in addiction by modulating synaptic GABA. Therefore, variants in these genes might predict risk/resilience for alcoholism. METHODS: This study included 3 populations that differed by ethnicity and alcoholism phenotype:...

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Identifiers

PMID: 26727527
DOI: 10.1111/acer.12929
PMCID: PMC4700558

Genes

GABBR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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