Article
Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample.
Alcoholism, clinical and experimental research - 1 Jul 2006
Dick Danielle M, Plunkett Jevon, Wetherill Leah Flury, Xuei Xiaoling, Goate Alison, Hesselbrock Victor, Schuckit Marc, Crowe Raymond, Edenberg Howard J, Foroud Tatiana
Abstract excerpt
BACKGROUND: A wealth of literature supports the role of gamma-aminobutyric acid (GABA) in neurobiological pathways contributing to alcohol dependence and related phenotypes. Animal studies have consistently tied rodent homologs of the GABAA receptor genes on human chromosome 5q to alcohol-related behaviors; however, human studies have produced mixed results. Family-based association analyses previously conducted...
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