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Article

Moderation of baclofen response by a GABAB receptor polymorphism: results from the BacALD randomized controlled trial.

Addiction (Abingdon, England) - 1 Dec 2018

Morley Kirsten C, Luquin Natasha, Baillie Andrew, Fraser Isabel, Trent Ronald J, Dore Glenys, Phung Nghi, Haber Paul S

Abstract excerpt

BACKGROUND AND AIMS: Baclofen has been shown to reduce alcohol consumption in alcohol-dependent individuals, but there is marked heterogeneity in response. An association between GABBR1 rs29220 and alcohol dependence has been demonstrated previously. The present study evaluated whether the response to baclofen is moderated by a single nucleotide polymorphism (rs29220) in the GABAB receptor subunit 1 gene...

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Source

Identifiers

PMID: 29968397
DOI: 10.1111/add.14373

Genes

GABBR1

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